integrin signaling pathway
| PAG Title | integrin signaling pathway |
| PAG ID | WAG000232 |
| Type | P |
| Source Link |  BioCarta |
| Publication Reference | NA |
| PAG Description | Integrins are cell surface receptors that interact with the extracellular matrix and mediate intracellular sigls in response to the extracellular matrix including cellular shape, mobility, and progression through the cell cycle. Integrins do not themselves possess a kise domain or enzymatic activity but rely on association with other sigling molecules to transmit sigls. Interactions between the extracellular matrix and the actin cytoskeleton commonly take place at focal adhesions on the cell surface that contain localized concentrations of integrins, sigling molecules, and cytoskeletal elements. Talin forms a direct interaction with the integrin cytoplasmic domain, and interacts with cytoskeletal elements (actin) and sigling factors. Paxillin and CAS also localize in focal adhesions and may serve as a scaffold for other integrin sigling components like FAK and src. Interaction of FAK, CAS and src may be required for integrin regulation of cell cycle progression. The CrkL adaptor protein may regulate downstream integrin sigling. Growth factor sigling pathways and the caveolin receptor exhibit important cross talk with integrin receptors in cellular responses like activation of map kise, proliferation and motility. |
| Species | Homo sapiens |
| nCoCo Score | 3,895 |
| Base PAG ID | WAG000232 |
| Human Phenotyte Annotation | |
| Curator | PAGER curation team |
| Curator Contact | PAGER-contact@googlegroups.com |
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